First Baby Born Using Uterus Transplanted From Deceased Donor: Doctors

The baby is the first to be delivered from a donated uterus from a dead donor

Researchers in Brazil released a groundbreaking study Tuesday on the first baby born to a woman with a transplanted uterus from a deceased donor.

In the Brazilian case, the recipient had been born without a uterus due to a condition called Mayer-Rokitansky-Küster-Hauser syndrome.

The donor was a 45-year-old woman who had died from a stroke, and her uterus was removed during a 10-hour procedure.

The healthy baby girl was born via cesarean section at Hospital das Clínicas, at the University of São Paulo School of Medicine, after her mother underwent a uterine transplant followed by an In vitro fertilization (IVF) pregnancy just seven months later.

The girl born in the Brazilian case was delivered via caesarean section at 35 weeks and three days, and weighed 2,550 grams, the case study said.

While womb transplants from living donors have been successful, womb transplants from deceased donors still need to be researched, as none of the deceased donor transplants has until now resulted in conception and birth.

Uterus transplantation was pioneered by Swedish doctor Mats Brannstrom, who has delivered eight children from women who got wombs from family members or friends.

The first successful childbirth following uterine transplant from a living donor took place in 2014 in Sweden, and there have been 10 others since then. Uterus transplantation, even from living donors, is still a very new procedure.

According to AFP (via MedicalXpress), the researchers have published their findings on the birth of a healthy baby girl in December 2017 following an operation to insert the donor uterus in 2016.

Both the mum and baby were discharged three days after birth, with an uneventful early follow-up.

Dr Deborah Davis said future consequences could arise from similar procedures
Dr Deborah Davis said future consequences could arise from similar procedures

"The number of people willing and committed to donate organs upon their own deaths are far larger than those of live donors, offering a much wider potential donor population".

It said the case involved connecting veins from the donor's uterus with the recipient's veins, as well as linking arteries, ligaments, and vaginal canals.

"There are still lots of things we don't understand about pregnancies, like how embryos implant, ' said Dr. Cesar Diaz, who co-authored an accompanying commentary in the journal". The baby weighed almost six pounds.

Tragically, the pregnancy was determined to be unviable six weeks after conception and was terminated, calling into doubt whether uteruses provided by deceased donors could feasibly carry a new life completely through gestation.

She received five immunosuppression drugs, as well as antimicrobials, anti-blood clotting treatment and aspirin while in hospital.

Next, the team will repeat the procedure in two more patients.

"The first uterus transplants from live donors were a medical milestone", added Dr Ejzenberg.

"This is a great alternative compared to live donor uterus transplants and therefore a really historic achievement", said Dr. Tullius, who is also a professor of surgery at Harvard University. The uterus is removed and immunosuppressants are stopped after birth, according to the Royal College of Obstetricians and Gynaecologists.

No. In order to keep the uterus after birth, the mother would have to continue taking immune system suppression medications which can pose risks. Uterine transplantation began in other countries where there are legal or ethical barriers to surrogacy-getting someone else to carry the pregnancy-O'Neill says.

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